Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.65 |
| ▸ | KDM5A | P29375 | 5/20 | 0.65 |
| ▸ | KDM2B | Q8NHM5 | 6/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095350 | 0.86 | KDM4C (0.67) | KDM4CKDM5AKDM2BKDM5BMAPK14 | |
| SCHEMBL17604576 | 0.85 | KDM4C (0.47) | KDM4CKDM5AKDM2BPHF8MAPK14 | |
| SCHEMBL17604535 | 0.84 | KDM4C (0.46) | KDM4CKDM5AKDM2BPHF8MAPK14 | |
| SCHEMBL16095130 | 0.81 | KDM4C (0.69) | KDM4CKDM5AKDM2BKDM5BPHF8 | |
| SCHEMBL16034821 | 0.79 | KDM4C (1.00) | KDM4CKDM5AKDM2BKDM5BPHF8 | |
| SCHEMBL17604573 | 0.77 | PKM (0.41) | KDM4CKDM5AKDM2BPHF8MAPK14 | |
| SCHEMBL20978940 | 0.76 | KDM4C (0.65) | KDM4CKDM5AKDM2BKDM5BPHF8 | |
| SCHEMBL16095598 | 0.73 | KDM4C (0.56) | KDM4CKDM5AKDM2BKDM5BPHF8 | |
| SCHEMBL16095312 | 0.72 | KDM4C (0.60) | KDM4CKDM5AKDM2BKDM5BMAPK14 | |
| SCHEMBL16034238 | 0.72 | KDM4C (1.00) | KDM4CKDM5AKDM2BKDM5BPHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |