Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604576 | 0.86 | KDM4C (0.47) | KDM4CKDM5APHF8KDM2BMAPK14 | |
| SCHEMBL16095596 | 0.84 | KDM4C (0.65) | KDM4CKDM5APHF8KDM2BMAPK14 | |
| SCHEMBL17604573 | 0.81 | PKM (0.41) | KDM4CKDM5APHF8KDM2BMAPK14 | |
| SCHEMBL16095130 | 0.80 | KDM4C (0.69) | KDM4CKDM5APHF8KDM2B | |
| SCHEMBL17604553 | 0.79 | KDM4C (0.73) | KDM4CKDM5APHF8KDM2BBRD4 | |
| SCHEMBL17604537 | 0.74 | KDM4C (0.40) | KDM4CKDM5APHF8KDM2BKCNH2 | |
| SCHEMBL17604533 | 0.72 | PHF8 (0.42) | KDM4CKDM5APHF8KDM2BMAPK14 | |
| SCHEMBL17604524 | 0.72 | PHF8 (0.41) | KDM4CKDM5APHF8KDM2BMAPK14 | |
| SCHEMBL16102461 | 0.71 | KDM4C (0.42) | KDM4CPHF8MAPK14KCNH2GRIN1 | |
| SCHEMBL17535739 | 0.71 | ALDH1A1 (0.48) | KDM4CKDM5APHF8KDM2BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |