Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850023 | 0.78 | L3MBTL1 (0.56) | L3MBTL1GAAKMT2APOLBTSHR | |
| SCHEMBL17607158 | 0.78 | GSK3B (0.51) | GAASMN1; SMN2KMT2APOLBTSHR | |
| SCHEMBL26789765 | 0.76 | L3MBTL1 (0.54) | L3MBTL1GAAKMT2ATSHRNPC1 | |
| SCHEMBL2678200 | 0.76 | KDM4E (0.48) | L3MBTL1GAASMN1; SMN2KMT2ATSHR | |
| SCHEMBL17607157 | 0.73 | MAPK7 (0.57) | GAA | |
| SCHEMBL7848797 | 0.72 | METAP1 (0.52) | L3MBTL1GAAKMT2APOLBTSHR | |
| SCHEMBL15452783 | 0.72 | L3MBTL1 (0.53) | L3MBTL1GAASMN1; SMN2KMT2APOLB | |
| SCHEMBL17607192 | 0.71 | KCNMA1 (0.45) | POLBLMNAKCNMA1KDM4E | |
| SCHEMBL13506055 | 0.70 | HPGD (0.62) | L3MBTL1GAAKMT2APOLBNPC1 | |
| SCHEMBL19476139 | 0.70 | KMT2A (0.56) | GAASMN1; SMN2KMT2ATSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |