Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607192 | 0.74 | KCNMA1 (0.45) | — | |
| SCHEMBL17607250 | 0.74 | PIM1 (0.55) | PIM1PIM3PIM2GSK3BMAPT | |
| SCHEMBL17607208 | 0.73 | MAPT (0.49) | GSK3BMAPTGSK3AATR | |
| SCHEMBL15103607 | 0.73 | PIM3 (0.79) | PIM1PIM3PIM2GSK3BMAPT | |
| SCHEMBL17622798 | 0.72 | MAPK7 (0.65) | GSK3BMAPTCSF1R | |
| SCHEMBL4445138 | 0.72 | PIM1 (1.00) | PIM1PIM3PIM2GSK3BMAPT | |
| SCHEMBL17622464 | 0.72 | MAPK7 (0.57) | CSF1R | |
| SCHEMBL17607258 | 0.72 | KCNMA1 (0.42) | — | |
| SCHEMBL14078174 | 0.72 | CSF1R (0.58) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL16519609 | 0.71 | PIM1 (0.72) | PIM1PIM3PIM2GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |