Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607192 | 0.91 | KCNMA1 (0.45) | KCNMA1TRPV1IKBKETBK1TMIGD3 | |
| SCHEMBL17607158 | 0.79 | GSK3B (0.51) | KDM4EPOLB | |
| SCHEMBL17607208 | 0.77 | MAPT (0.49) | KCNMA1KDM4EPOLB | |
| SCHEMBL20265692 | 0.72 | MAPK7 (0.66) | — | |
| SCHEMBL20265879 | 0.72 | MAPK7 (0.57) | — | |
| SCHEMBL17607253 | 0.72 | PIM1 (0.57) | — | |
| SCHEMBL17607182 | 0.68 | L3MBTL1 (0.53) | KCNMA1KDM4EPOLB | |
| SCHEMBL2781925 | 0.68 | KDM4E (0.61) | KDM4EPOLB | |
| SCHEMBL16257955 | 0.68 | AOC1 (0.65) | KDM4C | |
| SCHEMBL19781497 | 0.67 | AOC1 (0.53) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |