Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12592956 | 1.00 | ADORA2A (0.50) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL12592880 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL1760963 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL1760877 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL12592953 | 0.82 | CFTR (0.50) | ADORA2AADORA1ADORA2BADORA3HDAC1 | |
| SCHEMBL1760993 | 0.82 | CFTR (0.50) | ADORA2AADORA1ADORA2BADORA3HDAC1 | |
| SCHEMBL1760991 | 0.76 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL1761044 | 0.75 | ADORA2A (0.40) | ADORA2AADORA1ADORA2B | |
| SCHEMBL12592960 | 0.75 | ADORA2A (0.40) | ADORA2AADORA1ADORA2B | |
| SCHEMBL22063329 | 0.74 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |