Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12592960 | 1.00 | ADORA2A (0.40) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL2929522 | 0.89 | ADORA2B (0.37) | ADORA2AADORA1ADORA2BSCD | |
| SCHEMBL1760967 | 0.88 | PIK3CD (0.42) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL12592897 | 0.88 | PIK3CD (0.42) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL1761043 | 0.84 | PIK3CD (0.40) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL2931938 | 0.77 | PIK3CD (0.37) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL3047619 | 0.76 | RIPK1 (0.37) | ADORA2AADORA1ADORA2BPIK3CDPIK3CA | |
| SCHEMBL1760993 | 0.76 | CFTR (0.50) | ADORA2AADORA1ADORA2B | |
| SCHEMBL12592953 | 0.76 | CFTR (0.50) | ADORA2AADORA1ADORA2B | |
| SCHEMBL1760842 | 0.75 | ADORA2A (0.50) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |