Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12592880 | 1.00 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL1760963 | 1.00 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL1760991 | 0.94 | ADORA2A (0.46) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL4050561 | 0.85 | PIK3CD (0.41) | ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL4049256 | 0.85 | PIK3CD (0.41) | ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL13176908 | 0.84 | ADORA2A (0.48) | ADORA2AADORA1PIK3CDPIK3CAADORA3 | |
| SCHEMBL4052091 | 0.83 | ADORA2A (0.43) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL4049475 | 0.83 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL1760842 | 0.83 | ADORA2A (0.50) | ADORA2AADORA1ALDH1A1MAPTTSHR | |
| SCHEMBL12592956 | 0.83 | ADORA2A (0.50) | ADORA2AADORA1ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |
| WO-2007134958-A1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-29 | — | — | WO | disclosed |