Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 7/20 | 0.46 |
| ▸ | CDK8 | P49336 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608636 | 0.86 | LMNA (0.49) | JAK2JAK1LMNAMAPK1HSP90AA1 | |
| SCHEMBL17608363 | 0.81 | CCNC (0.69) | JAK2LMNACCNCCDK8MAPK1 | |
| SCHEMBL17608387 | 0.81 | CDK8 (0.68) | CCNCCDK8HSP90AA1CSNK1DHSP90AB1 | |
| SCHEMBL17608621 | 0.80 | CCNC (0.73) | CCNCCDK8CDK19 | |
| SCHEMBL17608642 | 0.78 | CCNC (0.71) | CCNCCDK8CSNK1DHTR2APASK | |
| SCHEMBL17608648 | 0.77 | CCNC (0.72) | CCNCCDK8CSNK1DHTR2APASK | |
| SCHEMBL17608234 | 0.76 | CCNC (0.76) | CCNCCDK8MAPK1HTR2APASK | |
| SCHEMBL13013280 | 0.73 | GSK3B (0.46) | JAK2JAK1 | |
| SCHEMBL30147526 | 0.71 | CCNC (0.50) | JAK2JAK1CCNCCDK8CSNK1D | |
| SCHEMBL4781046 | 0.71 | JAK2 (0.48) | JAK2JAK1LMNACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |