Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22189692 | 0.79 | L3MBTL1 (0.56) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15839871 | 0.77 | KDM4C (0.56) | L3MBTL1MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL21056732 | 0.76 | L3MBTL1 (0.65) | L3MBTL1MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL22290167 | 0.73 | NPSR1 (0.44) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17619675 | 0.71 | KDM4E (0.49) | L3MBTL1MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL22189724 | 0.71 | L3MBTL1 (0.55) | L3MBTL1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17610280 | 0.69 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL27170874 | 0.69 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL24469969 | 0.69 | KDM6B (0.41) | ALDH1A1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL15839759 | 0.68 | KDM4C (0.69) | L3MBTL1ALDH1A1HPGDKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194377-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044666-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |