Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22189724 | 0.88 | L3MBTL1 (0.55) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL6269745 | 0.84 | KDM4E (0.48) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL7519629 | 0.84 | CYP11B1 (0.51) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL22189609 | 0.82 | KDM4C (0.45) | L3MBTL1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL29581046 | 0.82 | KDM4C (0.45) | L3MBTL1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL22189659 | 0.80 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL17610282 | 0.79 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL22189722 | 0.79 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL845125 | 0.79 | ALDH1A1 (0.62) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL15839871 | 0.78 | KDM4C (0.56) | L3MBTL1ALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114126597-A | Fibroblast activation protein inhibitor | 普拉西斯生物技术有限责任公司 | 2022-03-01 | — | — | CN | disclosed |
| EP-3906024-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Praxis Biotech LLC (US) | 2021-11-10 | — | — | EP | disclosed |
| US-20200216417-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2020-07-09 | — | — | US | disclosed |
| WO-2020142742-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Praxis Biotech LLC (US) | 2020-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216417-A1 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | FAP, FIBP, FRS2 | L3MBTL1 4163/4885ALDH1A1 3702/4885KDM4E 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.