Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102217 | 0.94 | HTR6 (0.41) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097152 | 0.92 | HTR6 (0.37) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097149 | 0.90 | HTR6 (0.38) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17096913 | 0.86 | HTR6 (0.37) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097150 | 0.86 | GRM2 (0.41) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17096888 | 0.85 | HTR6 (0.42) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097130 | 0.85 | HTR6 (0.41) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17102183 | 0.84 | HTR6 (0.47) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17096912 | 0.84 | HTR6 (0.38) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097229 | 0.83 | HTR6 (0.39) | HTR6HTR2AHTR7CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140717-A9 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2016-03-24 | — | — | WO | disclosed |