Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102217 | 0.91 | HTR6 (0.41) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17096736 | 0.90 | HTR6 (0.43) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17096913 | 0.84 | HTR6 (0.37) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17610352 | 0.84 | HTR6 (0.41) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17096733 | 0.84 | HTR6 (0.54) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17096912 | 0.82 | HTR6 (0.38) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17097152 | 0.78 | HTR6 (0.37) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17097195 | 0.76 | GRM2 (0.41) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17097149 | 0.75 | HTR6 (0.38) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL17102155 | 0.75 | TRPM8 (0.39) | L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119763-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Iteos Therapeutics (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140717-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-09-24 | — | — | WO | disclosed |