Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612711 | 0.90 | NPC1 (0.46) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL17612699 | 0.88 | RXFP1 (0.45) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL17612696 | 0.87 | RXFP1 (0.44) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL12305112 | 0.86 | NPC1 (0.42) | TP53NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17612683 | 0.86 | NPC1 (0.44) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL10059653 | 0.86 | NHERF1 (0.49) | TP53NPC1RAB9ASMN1; SMN2FADS1 | |
| SCHEMBL17612688 | 0.85 | MEN1 (0.47) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL17612684 | 0.85 | RAB9A (0.52) | MAPTTP53NPC1RAB9ARXFP1 | |
| SCHEMBL12332996 | 0.84 | F10 (0.46) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10059600 | 0.84 | P2RX1 (0.44) | MAPTTP53NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9290450-B2 | Compounds and methods for treating inflammatory and fibrotic disorders | INTERMUNE, INC. (US) | 2016-03-22 | — | — | US | disclosed |