Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.81 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.81 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599491 | 0.90 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599442 | 0.90 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL29584677 | 0.90 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599452 | 0.90 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599447 | 0.85 | KEAP1 (0.71) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17612852 | 0.85 | KEAP1 (0.71) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17612859 | 0.85 | KEAP1 (0.71) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL24811433 | 0.84 | KEAP1 (0.89) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599417 | 0.84 | KEAP1 (0.89) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599488 | 0.84 | KEAP1 (0.89) | KEAP1NFE2L2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |