Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.71 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599447 | 1.00 | KEAP1 (0.71) | KEAP1NFE2L2NPSR1TSHRCYP2C19 | |
| SCHEMBL17612859 | 1.00 | KEAP1 (0.71) | KEAP1NFE2L2NPSR1TSHRCYP2C19 | |
| SCHEMBL17599417 | 0.89 | KEAP1 (0.89) | KEAP1NFE2L2NPSR1TSHRMEN1 | |
| SCHEMBL17599434 | 0.89 | KEAP1 (0.89) | KEAP1NFE2L2NPSR1TSHRMEN1 | |
| SCHEMBL17599488 | 0.89 | KEAP1 (0.89) | KEAP1NFE2L2NPSR1TSHRMEN1 | |
| SCHEMBL17599436 | 0.88 | KEAP1 (0.74) | KEAP1NFE2L2NPSR1TSHRMEN1 | |
| SCHEMBL17599548 | 0.86 | NPSR1 (0.53) | KEAP1NFE2L2NPSR1TSHRCYP2C19 | |
| SCHEMBL17612858 | 0.85 | KEAP1 (0.81) | KEAP1NFE2L2NPSR1TSHRMEN1 | |
| SCHEMBL17599442 | 0.83 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AALDH1A1 | |
| SCHEMBL17599452 | 0.83 | KEAP1 (1.00) | KEAP1NFE2L2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |