Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 9/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599475 | 1.00 | KEAP1 (0.59) | KEAP1NFE2L2NOTUMKMT2ABRD4 | |
| SCHEMBL17599420 | 1.00 | KEAP1 (0.59) | KEAP1NFE2L2NOTUMKMT2ABRD4 | |
| SCHEMBL17599508 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612896 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612905 | 0.80 | KEAP1 (0.61) | KEAP1NFE2L2NOTUMBRD4 | |
| SCHEMBL17599428 | 0.80 | KEAP1 (0.61) | KEAP1NFE2L2NOTUMBRD4 | |
| SCHEMBL17599512 | 0.79 | KEAP1 (0.71) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599511 | 0.79 | KEAP1 (0.71) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599427 | 0.77 | KEAP1 (0.71) | KEAP1NFE2L2NOTUM | |
| SCHEMBL24812743 | 0.77 | KEAP1 (0.87) | KEAP1NFE2L2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |