Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.46 |
| ▸ | BCR | P11274 | 12/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612966 | 0.93 | ABL1 (0.47) | ABL1BCRGPR142BRAF | |
| SCHEMBL17612988 | 0.91 | BRAF (0.46) | ABL1BCRBRAF | |
| SCHEMBL17612978 | 0.89 | ABL1 (0.57) | ABL1BCRBRAF | |
| SCHEMBL12464995 | 0.87 | GPR142 (0.46) | ABL1BCRGPR142BRAFABCG2 | |
| SCHEMBL12465330 | 0.84 | BRAF (0.52) | BRAFABCG2 | |
| SCHEMBL12465087 | 0.81 | BRAF (0.41) | ABL1BCRGPR142BRAF | |
| SCHEMBL12465240 | 0.81 | GPR142 (0.45) | ABL1BCRGPR142BRAF | |
| SCHEMBL12465245 | 0.81 | GPR142 (0.45) | ABL1BCRGPR142BRAF | |
| SCHEMBL12464937 | 0.81 | ABCG2 (0.40) | ABL1BCRGPR142BRAFABCG2 | |
| SCHEMBL12465241 | 0.80 | BRAF (0.47) | ABL1BCRGPR142BRAFABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |