Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 12/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612862 | 0.83 | KEAP1 (0.54) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599501 | 0.80 | KEAP1 (0.62) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612882 | 0.78 | CTSB (0.50) | KEAP1 | |
| SCHEMBL17612878 | 0.78 | KEAP1 (0.67) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612885 | 0.77 | KEAP1 (0.55) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612888 | 0.76 | KEAP1 (0.52) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612890 | 0.75 | KEAP1 (0.48) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612886 | 0.74 | KEAP1 (0.56) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612877 | 0.74 | KEAP1 (0.67) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612860 | 0.73 | KEAP1 (0.60) | KEAP1NFE2L2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |