Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612900 | 0.90 | CSF1R (0.43) | ABL1CSF1RLYNKITBRAF | |
| SCHEMBL12398051 | 0.87 | BRAF (0.51) | ABL1BCRBRAF | |
| SCHEMBL17612960 | 0.79 | DDR2 (0.49) | ABL1BCRKITBRAFDDR2 | |
| SCHEMBL12398062 | 0.77 | BRAF (0.54) | ABL1BCRBRAF | |
| SCHEMBL12398073 | 0.77 | ABL1 (0.51) | ABL1BCRBRAF | |
| SCHEMBL12397967 | 0.77 | BRAF (0.56) | ABL1BCRBRAF | |
| SCHEMBL17612916 | 0.76 | ABL1 (0.54) | ABL1BCRCSF1RLYNKIT | |
| SCHEMBL17612992 | 0.76 | ABL1 (0.50) | ABL1BCRBRAF | |
| SCHEMBL12398168 | 0.76 | ABL1 (0.50) | ABL1BCRBRAF | |
| SCHEMBL12397996 | 0.76 | BRAF (0.56) | ABL1BCRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |