Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 15/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 11/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612914 | 0.86 | DDR2 (0.49) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL12397002 | 0.86 | ABL1 (0.51) | DDR2BRAFDDR1ABL1BCR | |
| SCHEMBL17612997 | 0.82 | DDR2 (0.50) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL17612900 | 0.82 | CSF1R (0.43) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL12397448 | 0.81 | ABL1 (0.50) | DDR2ABL1BCR | |
| SCHEMBL12396980 | 0.79 | DDR2 (0.52) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL12397452 | 0.79 | DDR2 (0.54) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL12397101 | 0.79 | GPR142 (0.48) | DDR2BRAFABL1BCR | |
| SCHEMBL17612979 | 0.79 | ABL1 (0.41) | DDR2BRAFDDR1KITABL1 | |
| SCHEMBL17612971 | 0.77 | GPR142 (0.35) | DDR2BRAFDDR1KITABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |