Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.33 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.33 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.33 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL444000 | 0.98 | TGFBR1 (0.41) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL28049014 | 0.95 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL869214 | 0.95 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL895151 | 0.95 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL14949 | 0.91 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL446422 | 0.89 | TGFBR1 (0.38) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Hydrochloric Acid SCHEMBL15846120 | 0.88 | — | — | |
| Ammonia Solution, Strong SCHEMBL7047319 | 0.88 | — | — | |
| Potassium SCHEMBL3659436 | 0.88 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL7057093 | 0.87 | TGFBR1 (0.37) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737237-B2 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | PHODIA CHIMIE (FR) | 2010-06-15 | — | — | US | claimed |
| US-20060217285-A1 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | RHODIA CHIMIE (FR) | 2006-09-28 | — | — | US | claimed |
| US-9974424-B2 | Laminate cleaning implement | THE PROCTER & GAMBLE COMPANY (US) | 2018-05-22 | — | — | US | disclosed |
| US-20150144563-A1 | Articles Comprising Soil Absorbing Polymers and Processes for Making Same | THE PROCTER & GAMBLE COMPANY | 2015-05-28 | — | — | US | disclosed |
| US-20140366293-A1 | LAMINATE CLEANING IMPLEMENT | THE PROCTER & GAMBLE COMPANY | 2014-12-18 | — | — | US | disclosed |
| US-8852399-B2 | Polymer-containing articles of manufacture and methods for making same | THE PROCTER & GAMBLE COMPANY (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130059766-A1 | CLEANING COMPOSITIONS AND SOIL CAPTURE AGENT FOR CLEANING OBJECTS | THE PROCTER & GAMBLE COMPANY | 2013-03-07 | — | — | US | disclosed |
| US-20120055643-A1 | POLYMER-CONTAINING ARTICLES OF MANUFACTURE AND METHODS FOR MAKING SAME | THE PROCTER & GAMBLE COMPANY | 2012-03-08 | — | — | US | disclosed |