Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.33 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.33 |
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.32 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.33 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.33 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.33 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL869214 | 1.00 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL444000 | 0.98 | TGFBR1 (0.41) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL176133 | 0.95 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Trimethylammonium SCHEMBL28049014 | 0.95 | TGFBR1 (0.39) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Hydrochloric Acid SCHEMBL15846120 | 0.93 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL7057093 | 0.91 | TGFBR1 (0.37) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Hydrochloric Acid SCHEMBL6561920 | 0.91 | TGFBR1 (0.42) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL14949 | 0.91 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL446422 | 0.89 | TGFBR1 (0.38) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Dimethylamine SCHEMBL8512095 | 0.88 | TGFBR1 (0.41) | TGFBR1PLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2579972-A1 | METHOD FOR PREPARING A NON-IONIC SURFACTANT STABLE PERSONAL CARE DISPERSION | The Procter and Gamble Company (US) | 2013-04-17 | — | — | EP | claimed |
| EP-1976888-B1 | PROCESS FOR PREPARING A COPOLYMER WITH CONTROLLED ARCHITECTURE, OF TELOMER OR BLOCK COPOLYMER TYPE, OBTAINED FROM VINYL PHOSPHONATE MONOMERS, BY IODINE TRANSFER POLYMERIZATION | RHODIA OPERATIONS (FR) | 2012-06-13 | — | — | EP | claimed |
| US-7737237-B2 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | PHODIA CHIMIE (FR) | 2010-06-15 | — | — | US | claimed |
| US-20090087398-A1 | Method for Treating Damaged Hair | THE PROCTER & GAMBLE COMPANY | 2009-04-02 | — | — | US | claimed |
| US-20090053165-A1 | Method for Treating Damaged Hair | THE PROCTER & GAMBLE COMPANY | 2009-02-26 | — | — | US | claimed |
| US-7473730-B2 | Method for depositing a polymer onto a surface by applying a composition onto said surface | RHODIA CHIMIE (FR) | 2009-01-06 | — | — | US | claimed |
| US-20080206355-A1 | Composition comprising a particulate zinc material, a pyrithione or a polyvalent metal salt of a pyrithione and a synthetic cationic polymer | THE PROCTER & GAMBLE COMPANY | 2008-08-28 | — | — | US | claimed |
| US-20060217285-A1 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | RHODIA CHIMIE (FR) | 2006-09-28 | — | — | US | claimed |
| US-20050180937-A1 | Method for depositing a polymer onto a surface by applying a composition onto said surface | CADENA NATALIE (US) | 2005-08-18 | — | — | US | claimed |
| US-20210315791-A1 | SHAMPOO COMPOSITION WITH NON-SULFATE SURFACTANT AND COMPLEXATION COMPOUND FORMING A COACERVATE | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2021-10-14 | — | — | US | disclosed |
| US-10912719-B2 | Personal care composition and method of making | THE PROCTER AND GAMBLE COMPANY (US) | 2021-02-09 | — | — | US | disclosed |
| WO-2020030732-A1 | SHAMPOO COMPOSITION WITH NON-SULFATE SURFACTANT AND COMPLEXATION COMPOUND FORMING A COACERVATE | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2020-02-13 | — | — | WO | disclosed |
| US-20160106663-A1 | PERSONAL CARE COMPOSITION AND METHOD OF MAKING | THE PROCTER & GAMBLE COMPANY | 2016-04-21 | — | — | US | disclosed |
| US-20160095809-A1 | METHOD OF IMPROVED VOLUME AND COMBABILITY USING PERSONAL CARE COMPOSITION COMPRISING A PRE-EMULSIFIED FORMULATION | THE PROCTER & GAMBLE COMPANY | 2016-04-07 | — | — | US | disclosed |
| US-20060234901-A1 | Polymer-fluorosurfactant associative complexes | CLOROX COMPANY, THE | 2006-10-19 | — | — | US | disclosed |
| US-20050245650-A1 | Method for preparing an emulsion by diluting an emulsifiable concentrate comprising an amphiphilic copolymer | RHODIA CHIMIE (FR) | 2005-11-03 | — | — | US | disclosed |
| US-20050203256-A1 | Poymer obtained by means of controlled radical polymerisation comprising at least one boronate function, association thereof with a ligand compound and uses of same | RHODIA CHIMIE (FR) | 2005-09-15 | — | — | US | disclosed |
| US-20050181225-A1 | Use of block copolymers bearing phosphate and/or phosphonate functions as adhesion promoters or as protecting agents against the corrosion of a metallic surface | CHIMIE, RHODIA (FR) | 2005-08-18 | — | — | US | disclosed |
| US-20050176863-A1 | Rare earth aggregate formulation using di-block copolmers | RHODIA INC. | 2005-08-11 | — | — | US | disclosed |
| WO-2003035791-A1 | COMPOSITION FOR AVOIDING OR REDUCING THE BUILD-UP OF ICE AND SNOW, METHOD FOR PRODUCTION AND USE OF SAID COMPOSITION | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10912719-B2 | Personal care composition and method of making | CUTA, POLR1C, KRT18 | MMP1 1648/4885MMP8 2785/4885CHRNB4 4509/4885 |
| US-20080206355-A1 | Composition comprising a particulate zinc material, a pyrithione or a polyvalent metal salt of a pyrithione and a synthetic cationic polymer | SLC39A3, SLC39A14, SLC30A7 | MMP1 3740/4885MMP8 4265/4885CHRNB4 862/4885 |
| US-20090053165-A1 | Method for Treating Damaged Hair | PLOD3, CUTA, SGMS2 | MMP1 337/4885MMP8 1330/4885CHRNB4 4416/4885 |
| US-20160095809-A1 | METHOD OF IMPROVED VOLUME AND COMBABILITY USING PERSONAL CARE COMPOSITION COMPRISING A PRE-EMULSIFIED FORMULATION | POLR1C, SGMS1, CERT1 | MMP1 71/4885MMP8 216/4885CHRNB4 4228/4885 |
| US-20090087398-A1 | Method for Treating Damaged Hair | LPO, MAG, CUTA | MMP1 922/4885MMP8 1503/4885CHRNB4 4379/4885 |
| US-20210315791-A1 | SHAMPOO COMPOSITION WITH NON-SULFATE SURFACTANT AND COMPLEXATION COMPOUND FORMING A COACERVATE | PSAP, SPAST, SYMPK | MMP1 930/4885MMP8 1279/4885CHRNB4 3249/4885 |
| US-20160106663-A1 | PERSONAL CARE COMPOSITION AND METHOD OF MAKING | CUTA, POLR1C, KRT18 | MMP1 1648/4885MMP8 2785/4885CHRNB4 4509/4885 |
| US-20050180937-A1 | Method for depositing a polymer onto a surface by applying a composition onto said surface | C5, ITGB5, MMAB | MMP1 1366/4885MMP8 3192/4885CHRNB4 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.