Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.34 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | DDT | P30046 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599373 | 0.81 | KMT2A (0.46) | NR1H4AKR1C3AKR1C2 | |
| SCHEMBL17613339 | 0.75 | SERPINE1 (0.41) | NR1H4AKR1C3AKR1C2SYKAXL | |
| SCHEMBL17613338 | 0.74 | NR1H4 (0.41) | NR1H4AKR1C3AKR1C2AXL | |
| SCHEMBL17613384 | 0.73 | NR1H4 (0.45) | NR1H4AKR1C3AKR1C2AXL | |
| SCHEMBL17613335 | 0.72 | ABCG2 (0.37) | NR1H4AKR1C3AKR1C2AXL | |
| SCHEMBL17613336 | 0.71 | NR1H4 (0.39) | NR1H4AKR1C3AKR1C2AXL | |
| SCHEMBL17613380 | 0.71 | PTGER1 (0.37) | AKR1C3AKR1C2PTGFR | |
| SCHEMBL17613326 | 0.70 | NR1H4 (0.41) | NR1H4AKR1C3AKR1C2AXL | |
| SCHEMBL15984742 | 0.69 | AKR1C3 (0.51) | NR1H4AKR1C3AKR1C2SYKGRM5 | |
| SCHEMBL17613314 | 0.69 | NR1H4 (0.52) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |