Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 11/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613344 | 0.82 | FABP4 (0.41) | FABP4FABP5 | |
| SCHEMBL17613334 | 0.82 | TTR (0.35) | PTGER1PTGFREP300CREBBPRORC | |
| SCHEMBL17599370 | 0.79 | ALDH1A1 (0.53) | FABP4MEN1KMT2AFABP5 | |
| SCHEMBL17613349 | 0.76 | SLC6A4 (0.36) | FABP4MEN1KMT2AFABP5 | |
| SCHEMBL17613338 | 0.71 | NR1H4 (0.41) | PTGER1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL17613384 | 0.71 | NR1H4 (0.45) | AKR1C4AKR1C3AKR1C2AKR1C1FABP4 | |
| SCHEMBL17613328 | 0.71 | NR1H4 (0.39) | PTGFRAKR1C3AKR1C2 | |
| SCHEMBL17599333 | 0.70 | PTK2B (0.52) | FABP4MEN1KMT2AFABP5 | |
| SCHEMBL17599384 | 0.69 | PTK2B (0.53) | FABP4MEN1KMT2AFABP5 | |
| SCHEMBL17613335 | 0.69 | ABCG2 (0.37) | AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |