Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599329 | 0.85 | KMT2A (0.55) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL17599349 | 0.84 | MEN1 (0.43) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL17613328 | 0.81 | NR1H4 (0.39) | AKR1C3AKR1C2NR1H4 | |
| SCHEMBL17599408 | 0.76 | BRD4 (0.36) | KMT2ADNMT3BMCL1 | |
| SCHEMBL17599510 | 0.75 | KMT2A (0.53) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL17599396 | 0.75 | KEAP1 (0.38) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL17599382 | 0.74 | WDR5 (0.45) | KMT2AKDM4EMEN1TSHRMCL1 | |
| SCHEMBL17599346 | 0.73 | CDC25B (0.45) | KMT2AALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL17599368 | 0.72 | KDM4E (0.48) | KMT2AKDM4EMEN1AKR1C3AKR1C2 | |
| SCHEMBL17599380 | 0.72 | MEN1 (0.44) | KMT2AALDH1A1KDM4EMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |