Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 4/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613749 | 0.92 | CYP2D6 (0.36) | CYP2D6TSHRMAOAHTR3AHRH3 | |
| SCHEMBL17613594 | 0.83 | HRH4 (0.34) | CHRM2CHRM3CHRM4CHRM1CYP1A2 | |
| SCHEMBL17613606 | 0.81 | TSHR (0.37) | CYP2D6TSHRMAOAHTR3AHRH3 | |
| SCHEMBL17613734 | 0.79 | THRA (0.31) | — | |
| SCHEMBL17613688 | 0.77 | KDM4E (0.37) | CYP2D6TSHRMAOAHTR3AHRH3 | |
| SCHEMBL17613772 | 0.77 | TDP1 (0.32) | TSHRTDP1ALDH1A1 | |
| SCHEMBL12022640 | 0.76 | — | — | |
| SCHEMBL17613692 | 0.75 | TSHR (0.36) | CYP2D6TSHRMAOAHTR3AHRH3 | |
| SCHEMBL14533260 | 0.74 | MEN1 (0.39) | CYP2D6TSHRHTR3AHRH3CHRM2 | |
| SCHEMBL10004390 | 0.74 | MEN1 (0.52) | CYP2D6TSHRMAOAHTR3AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346883-B1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2016-03-23 | — | — | EP | disclosed |