Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613688 | 0.92 | KDM4E (0.37) | TSHRCYP2D6MAOAHTR3AHRH3 | |
| SCHEMBL17613606 | 0.85 | TSHR (0.37) | TSHRCYP2D6MAOAHTR3AHRH3 | |
| SCHEMBL17613686 | 0.83 | DNM1 (0.34) | TSHRPAOXSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17613731 | 0.79 | THRA (0.31) | SMN1; SMN2KDM4ETHRBCHRM2CHRM1 | |
| SCHEMBL17613749 | 0.77 | CYP2D6 (0.36) | TSHRCYP2D6MAOAHTR3AHRH3 | |
| SCHEMBL17613698 | 0.76 | TSHR (0.43) | TSHRSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL12022625 | 0.76 | KDM4E (0.31) | KDM4E | |
| SCHEMBL17613607 | 0.75 | CYP2D6 (0.35) | TSHRCYP2D6MAOAHTR3AHRH3 | |
| SCHEMBL12022645 | 0.75 | — | — | |
| SCHEMBL17613689 | 0.75 | KDM4E (0.35) | PAOXSMN1; SMN2KDM4ETHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346883-B1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2016-03-23 | — | — | EP | disclosed |