Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.30 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581840 | 0.89 | ALDH1A1 (0.41) | GAAALDH1A1PTGDR2S1PR1BRD4 | |
| SCHEMBL17613863 | 0.86 | GAA (0.34) | GAAALDH1A1PTGDR2MAPTPOLB | |
| SCHEMBL2592452 | 0.85 | ALDH1A1 (0.42) | GAAALDH1A1PTGDR2S1PR1POLB | |
| SCHEMBL2592351 | 0.84 | ALDH1A1 (0.46) | GAAALDH1A1BRD4KDM4E | |
| SCHEMBL17614008 | 0.83 | HSD17B1 (0.45) | GAAPTGDR2BRD4FABP4 | |
| SCHEMBL17614020 | 0.82 | ALDH1A1 (0.43) | GAAALDH1A1S1PR1BRD4MAPT | |
| SCHEMBL14736996 | 0.80 | ALDH1A1 (0.47) | GAAALDH1A1S1PR1MAPTPOLB | |
| SCHEMBL17614015 | 0.78 | MAOB (0.34) | GAAALDH1A1MAPT | |
| SCHEMBL2593971 | 0.77 | ALDH1A1 (0.43) | GAAALDH1A1S1PR1MAPTPOLB | |
| SCHEMBL2588136 | 0.77 | ALDH1A1 (0.49) | GAAALDH1A1S1PR1BRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |