Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27987992 | 0.85 | KDM4E (0.50) | KDM4EL3MBTL1THRATHRBKMT2A | |
| SCHEMBL544330 | 0.85 | NQO1 (0.50) | KDM4EGPR84L3MBTL1KMT2ANPC1 | |
| SCHEMBL12885024 | 0.82 | KDM4E (0.69) | KDM4EGPR84L3MBTL1THRATHRB | |
| SCHEMBL14473813 | 0.79 | GAA (0.59) | KDM4EGPR84L3MBTL1KMT2ANPC1 | |
| SCHEMBL3790208 | 0.79 | KDM4E (0.51) | KDM4EGPR84L3MBTL1THRATHRB | |
| SCHEMBL24262858 | 0.78 | GPR84 (0.50) | KDM4EGPR84L3MBTL1THRATHRB | |
| SCHEMBL256301 | 0.78 | KDM4E (0.46) | KDM4EL3MBTL1THRATHRBKMT2A | |
| SCHEMBL15625385 | 0.78 | L3MBTL1 (0.71) | KDM4EGPR84L3MBTL1THRATHRB | |
| SCHEMBL20503253 | 0.78 | KDM4E (0.63) | KDM4EL3MBTL1THRATHRBKMT2A | |
| SCHEMBL3785877 | 0.78 | DRD4 (0.54) | KDM4EL3MBTL1THRATHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723744-B1 | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-23 | — | — | EP | disclosed |