SCHEMBL17614636

SCHEMBL17614636

Cc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ncc1CO

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 11/20 0.52
GRM5 P41594 10/20 0.52
WNT3A P56704 1/20 0.49
GPR119 Q8TDV5 3/20 0.45
CYP11B2 P19099 1/20 0.44
PDK4 Q16654 1/20 0.44
NAMPT P43490 1/20 0.44
CDK9 P50750 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25480363 0.91 GRM1 (0.51) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL23703974 0.88 GRM1 (0.53) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL18409268 0.86 GRM1 (0.52) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL18409265 0.86 GRM1 (0.52) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL19203191 0.85 GRM1 (0.53) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL23730448 0.82 GRM1 (0.56) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL16844855 0.82 GRM1 (0.48) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL23703330 0.81 WNT3A (0.57) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL29723480 0.81 WNT3A (0.57) GRM1GRM5WNT3AGPR119CYP11B2
SCHEMBL23730450 0.81 GRM1 (0.52) GRM1GRM5WNT3AGPR119CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10472350-B2 Soluble guanylate cyclase activators and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-11-12 US disclosed
US-10472350-B2 Soluble guanylate cyclase activators and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-11-12 US disclosed
US-20180194756-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-12 US disclosed
US-20180194756-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-12 US disclosed
US-20180194756-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-07-12 US disclosed
US-9938260-B2 Soluble guanylate cyclase activators and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-04-10 US disclosed
US-9938260-B2 Soluble guanylate cyclase activators and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-04-10 US disclosed
US-9938260-B2 Soluble guanylate cyclase activators and their use GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-04-10 US disclosed
US-20170305888-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-10-26 US disclosed
US-20170305888-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-10-26 US disclosed
US-20170305888-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-10-26 US disclosed
WO-2016042536-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-03-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170305888-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GUCY1A2, GUCY1A1, GUCY1B1 GRM1 2234/4885GRM5 1471/4885WNT3A 3081/4885
US-10472350-B2 Soluble guanylate cyclase activators and their use GUCY1A2, GUCY1A1, GUCY1B2 GRM1 2485/4885GRM5 1551/4885WNT3A 3121/4885
US-20180194756-A1 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE GUCY1A2, GUCY1A1, GUCY1B1 GRM1 2234/4885GRM5 1471/4885WNT3A 3081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.