Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | CASP6 | P55212 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.63 |
| ▸ | KIF11 | P52732 | 1/20 | 0.61 |
| ▸ | CTSV | O60911 | 2/20 | 0.57 |
| ▸ | CTSL | P07711 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12039630 | 0.96 | NPC1 (0.93) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL21972973 | 0.95 | NPC1 (0.90) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL13933160 | 0.90 | NPC1 (0.81) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL10861569 | 0.89 | MEN1 (0.80) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL2756508 | 0.87 | MEN1 (0.77) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL29355013 | 0.86 | NPC1 (0.76) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL29475421 | 0.86 | NPC1 (0.76) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL276094 | 0.86 | NPC1 (0.76) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL10078171 | 0.85 | MEN1 (0.74) | MEN1POLBKMT2ANPC1HPGD | |
| SCHEMBL30704438 | 0.84 | MEN1 (0.73) | MEN1POLBKMT2ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2019-10-15 | — | — | US | disclosed |
| WO-2016046759-A2 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS LTD. (IT) | 2016-03-31 | — | — | WO | disclosed |
| US-20160083358-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2016-03-24 | — | — | US | disclosed |
| US-20160083358-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083358-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN10, ATXN2, ATXN2L | MEN1 3654/4885POLB 1157/4885KMT2A 205/4885 |
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | ATXN10, ATXN2, ATXN2L | MEN1 3654/4885POLB 1157/4885KMT2A 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.