Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HPRT1 | P00492 | 8/20 | 0.59 |
| ▸ | POLA1 | P09884 | 1/20 | 0.58 |
| ▸ | POLG | P54098 | 1/20 | 0.58 |
| ▸ | PNP | P00491 | 9/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17617331 | 0.92 | POLB (0.59) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL16063251 | 0.91 | POLB (0.71) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL16063241 | 0.91 | POLB (0.71) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL16075000 | 0.91 | POLB (0.71) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17617664 | 0.91 | POLB (0.62) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17617338 | 0.90 | POLB (0.56) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17617566 | 0.90 | PNP (0.56) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17617336 | 0.90 | PNP (0.56) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17617335 | 0.90 | PNP (0.56) | POLBHPRT1POLA1POLGPNP | |
| SCHEMBL17622593 | 0.89 | POLB (0.58) | POLBHPRT1POLA1POLGPNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015095-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-01-18 | — | — | US | disclosed |
| US-9801884-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-31 | — | — | US | disclosed |
| US-9775852-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-03 | — | — | US | disclosed |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-09 | — | — | US | disclosed |
| US-9493493-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015095-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | POLB 29/4885HPRT1 52/4885POLA1 97/4885 |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | POLB 29/4885HPRT1 52/4885POLA1 97/4885 |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | POLB 29/4885HPRT1 52/4885POLA1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.