Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174699 | 0.90 | ADORA3 (0.60) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL3811896 | 0.85 | ADORA3 (0.57) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL3757171 | 0.83 | ADORA3 (0.59) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL117535 | 0.82 | ADORA3 (0.69) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL31031138 | 0.82 | ADORA3 (0.75) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL118463 | 0.82 | ACE2 (0.58) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL13056300 | 0.81 | ADORA3 (0.62) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL176174 | 0.80 | ADORA3 (0.61) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL1421560 | 0.77 | ACE2 (0.69) | ADORA3PPARGACE2ABCB1MAPT | |
| SCHEMBL118391 | 0.77 | ADORA3 (0.61) | ADORA3PPARGACE2ABCB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424541-A2 | PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT | Limerick BioPharma, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |