Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.74 |
| ▸ | PDE4A | P27815 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21861569 | 0.93 | TRPA1 (0.77) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL21861581 | 0.85 | TRPA1 (0.82) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL17619850 | 0.85 | TRPA1 (1.00) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL660023 | 0.83 | ADORA2B (0.76) | TRPA1LMNAMAPTADORA2BSMN1; SMN2 | |
| SCHEMBL17619853 | 0.83 | TRPA1 (1.00) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL16028209 | 0.81 | PDE4A (0.58) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL9293614 | 0.80 | ADORA2B (0.71) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL9293292 | 0.80 | PDE4A (0.62) | TRPA1PDE4ALMNACYP1A2NFKB1 | |
| SCHEMBL11610987 | 0.79 | PDE4A (0.74) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL9297147 | 0.78 | PDE4A (0.80) | TRPA1PDE4ALMNACYP1A2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044792-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2016-03-24 | — | — | WO | disclosed |