Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12187315 | 0.80 | NPC1 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL11251526 | 0.78 | SMN1; SMN2 (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL9509522 | 0.77 | NPC1 (0.66) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14355159 | 0.73 | SLC11A2 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL9866549 | 0.73 | LMNA (0.51) | SMN1; SMN2LMNACYP3A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL11704765 | 0.71 | LMNA (0.50) | SMN1; SMN2LMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL9209968 | 0.71 | NPC1 (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7624845 | 0.71 | MC4R (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL21573719 | 0.70 | NPC1 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL68470 | 0.70 | CYP2C19 (0.68) | ALDH1A1SMN1; SMN2LMNACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150177211-A1 | Chemical probe compounds that become fluorescent upon reduction, and methods for their use | LIFE TECHNOLOGIES CORP (US) | 2015-06-25 | — | — | US | disclosed |
| US-8962853-B2 | Chemical probe compounds that become fluorescent upon reduction, and methods for their use | Life Technologies Corporation (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140127679-A1 | Chemical probe compounds that become fluorescent upon reduction, and methods for their use | Life Technologies Corporation (US) | 2014-05-08 | — | — | US | disclosed |
| US-8546580-B2 | Chemical probe compounds that become fluorescent upon reduction, and methods for their use | Life Technologies Corporation (US) | 2013-10-01 | — | — | US | disclosed |
| EP-1853598-B1 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE | LIFE TECHNOLOGIES CORP (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20110117591-A1 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE | Life Technologies Corporation (US) | 2011-05-19 | — | — | US | disclosed |
| US-20080254501-A1 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE | INVITROGEN CORPORATION (US) | 2008-10-16 | — | — | US | disclosed |
| EP-1853598-A2 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE | Molecular Probes, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006094104-A2 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE | MOLECULAR PROBES, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060199242-A1 | Chemical probe compounds that become fluorescent upon reduction, and methods for their use | MOLECULAR PROBES, INC | 2006-09-07 | — | — | US | disclosed |