⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399500 | 0.76 | — | — | |
| SCHEMBL28242954 | 0.76 | — | — | |
| SCHEMBL1660131 | 0.76 | — | — | |
| SCHEMBL15891880 | 0.73 | RECQL (0.36) | — | |
| SCHEMBL31658855 | 0.73 | RECQL (0.36) | — | |
| SCHEMBL374261 | 0.73 | HRH1 (0.38) | — | |
| SCHEMBL16033555 | 0.73 | KDM4E (0.42) | — | |
| SCHEMBL31051471 | 0.73 | — | — | |
| SCHEMBL17000231 | 0.71 | NOS3 (0.36) | — | |
| SCHEMBL1767766 | 0.71 | GRN (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937064-B2 | Pyrazolo[1,5-a]pyrimidines useful as JAK2 inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-01-20 | — | — | US | disclosed |
| US-20110118255-A1 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-19 | — | — | US | disclosed |
| EP-2252618-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009085913-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-09 | — | — | WO | disclosed |