Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.65 |
| ▸ | CDK2 | P24941 | 7/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CCNH | P51946 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14990749 | 0.90 | CDK5 (0.71) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL2793739 | 0.89 | CDK5 (0.52) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL17106477 | 0.87 | CDK5 (0.61) | CDK5CDK5R1CDK2CCNA2CDK1 | |
| SCHEMBL9959309 | 0.86 | CDK5 (0.49) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL9959904 | 0.86 | CDK2 (0.67) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| Hydrochloric Acid SCHEMBL22999742 | 0.85 | CDK5 (0.60) | CDK5CDK5R1CDK2CCNA2CDK1 | |
| SCHEMBL9958931 | 0.84 | GRM5 (0.55) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL9959907 | 0.84 | CDK5 (0.70) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL9958935 | 0.84 | GRM5 (0.70) | CDK5CDK5R1CDK2CCNA2HTR2C | |
| SCHEMBL9959983 | 0.83 | CDK5 (0.69) | CDK5CDK5R1CDK2CCNA2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102088-A1 | PIPERIDYLPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASE INHIBITORS AND OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102088-A1 | PIPERIDYLPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASE INHIBITORS AND OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102088-A1 | PIPERIDYLPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASE INHIBITORS AND OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-9296747-B1 | Piperidylpyrimidine derivatives as modulators of protein kinase inhibitors and of vascular endothelial growth factor receptor 2 | ALLERGAN, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296747-B1 | Piperidylpyrimidine derivatives as modulators of protein kinase inhibitors and of vascular endothelial growth factor receptor 2 | ALLERGAN, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296747-B1 | Piperidylpyrimidine derivatives as modulators of protein kinase inhibitors and of vascular endothelial growth factor receptor 2 | ALLERGAN, INC. (US) | 2016-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102088-A1 | PIPERIDYLPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASE INHIBITORS AND OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | KDR, PTGFR, TEK | CDK5 72/4885CDK5R1 35/4885CDK2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.