Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.70 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.70 |
| ▸ | CDK2 | P24941 | 5/20 | 0.70 |
| ▸ | CDK1 | P06493 | 2/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.70 |
| ▸ | GRM5 | P41594 | 4/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.55 |
| ▸ | MERTK | Q12866 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23020864 | 0.89 | CDK5 (0.67) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| Hydrochloric Acid SCHEMBL22999673 | 0.88 | CDK5 (0.65) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL22999621 | 0.87 | CDK5 (0.51) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL9958935 | 0.85 | GRM5 (0.70) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL9958931 | 0.85 | GRM5 (0.55) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL9959330 | 0.85 | CDK5 (0.71) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL9959904 | 0.85 | CDK2 (0.67) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL17620607 | 0.84 | CDK5 (0.65) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL9954342 | 0.83 | MAOB (0.58) | CDK5CDK5R1CCNA2CDK2CDK1 | |
| SCHEMBL22999790 | 0.80 | CDK5 (0.55) | CDK5CDK5R1CCNA2CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |