SCHEMBL9959983

SCHEMBL9959983

COc1ccc(Nc2ncc3c(n2)CCNC3)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 3/20 0.69
CDK5R1 Q15078 3/20 0.69
GRM5 P41594 2/20 0.52
MAPT P10636 2/20 0.52
CCNA2 P20248 2/20 0.51
CDK2 P24941 2/20 0.51
ALDH1A1 P00352 3/20 0.50
MAOA P21397 2/20 0.50
MAOB P27338 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KDM4E B2RXH2 1/20 0.50
USP2 O75604 1/20 0.50
HPGD P15428 1/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KDR P35968 8/20 0.49
PDGFRB P09619 1/20 0.49
AURKA O14965 1/20 0.49
SYK P43405 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23020736 0.88 CDK5 (0.66) CDK5CDK5R1GRM5MAPTCCNA2
SCHEMBL9959676 0.88 LMNA (0.54) CDK5CDK5R1MAPTCCNA2CDK2
Hydrochloric Acid SCHEMBL22999875 0.87 CDK5 (0.64) CDK5CDK5R1GRM5MAPTCCNA2
SCHEMBL9959330 0.86 CDK5 (0.71) CDK5CDK5R1GRM5CCNA2CDK2
SCHEMBL9959904 0.86 CDK2 (0.67) CDK5CDK5R1GRM5MAPTCCNA2
SCHEMBL2793739 0.85 CDK5 (0.52) CDK5CDK5R1GRM5CCNA2CDK2
SCHEMBL9959309 0.83 CDK5 (0.49) CDK5CDK5R1GRM5MAPTCCNA2
SCHEMBL17620607 0.83 CDK5 (0.65) CDK5CDK5R1GRM5MAPTCCNA2
SCHEMBL9959736 0.82 MAPT (0.55) CDK5CDK5R1MAPTCCNA2CDK2
SCHEMBL17620613 0.81 PDGFRB (0.58) KDRPDGFRBAURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012085167-A1 METABOTROPIC GLUTAMATE RECEPTOR MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-06-28 WO claimed
WO-2012085167-A1 METABOTROPIC GLUTAMATE RECEPTOR MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-06-28 WO disclosed