Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30584896 | 0.83 | ALDH1A1 (0.58) | ALDH1A1MAPTSMN1; SMN2POLBMAPK1 | |
| SCHEMBL176218 | 0.83 | SCN10A (0.45) | SCN10AALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL162574 | 0.81 | SCN10A (0.49) | SCN10AALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL162488 | 0.81 | SCN10A (0.49) | SCN10AALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL4529235 | 0.78 | CYP1A2 (0.60) | ALDH1A1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL4529230 | 0.78 | CYP1A2 (0.60) | ALDH1A1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL174317 | 0.75 | S1PR4 (0.49) | ALDH1A1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL174328 | 0.75 | S1PR4 (0.49) | ALDH1A1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL24844551 | 0.74 | NR1H4 (0.60) | SMN1; SMN2GAALMNAHTTAOC3 | |
| SCHEMBL30584793 | 0.74 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |