Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.68 |
| ▸ | STAT3 | P40763 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.50 |
| ▸ | WNT3A | P56704 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27712247 | 0.81 | KDM4E (0.67) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL29805260 | 0.81 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL498053 | 0.81 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL19675209 | 0.79 | KDM4E (0.57) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL29781840 | 0.79 | KDM4E (0.67) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL217086 | 0.79 | KDM4E (0.67) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL25380488 | 0.78 | KDM4E (0.71) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL11485891 | 0.78 | KDM4E (0.71) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL5435670 | 0.77 | KDM4E (0.69) | KDM4ESTAT3HIF1AYTHDC1NPC1 | |
| SCHEMBL959364 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170305882-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170275269-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | US | disclosed |
| US-20170273980-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | US | disclosed |
| US-20170275270-A1 | BENZYL SUBSTITUTED INDAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | US | disclosed |
| WO-2016042080-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016041925-A1 | BENZYL SUBSTITUTED INDAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016042081-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016042084-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275270-A1 | BENZYL SUBSTITUTED INDAZOLES | UGT2B7, CYP3A43, CYP3A7 | KDM4E 2538/4885STAT3 4365/4885HIF1A 3332/4885 |
| US-20170273980-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 INHIBITORS | BUB1, BUB1B, BUB3 | KDM4E 1627/4885STAT3 3783/4885HIF1A 2987/4885 |
| US-20170275269-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BUB1, BUB1B, BUB3 | KDM4E 1582/4885STAT3 3323/4885HIF1A 2878/4885 |
| US-20170305882-A1 | BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS | BUB1, BUB1B, BUB3 | KDM4E 1582/4885STAT3 3323/4885HIF1A 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.