Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623221 | 0.86 | CHEK1 (0.41) | LRRK2CHEK1CHEK2FFAR2 | |
| SCHEMBL13103472 | 0.73 | LRRK2 (0.41) | LRRK2ALDH1A1 | |
| SCHEMBL21940807 | 0.72 | LRRK2 (0.44) | LRRK2CHEK1CHEK2 | |
| SCHEMBL16440191 | 0.71 | GAA (0.43) | LRRK2ALDH1A1 | |
| SCHEMBL19241974 | 0.71 | KDM4E (0.54) | LRRK2CHEK1ALDH1A1 | |
| SCHEMBL21941085 | 0.71 | LRRK2 (0.50) | LRRK2CHEK1CHEK2ALDH1A1 | |
| SCHEMBL21262293 | 0.70 | GRIN2D (0.43) | LRRK2CHEK1CHEK2ALDH1A1 | |
| SCHEMBL18436051 | 0.70 | LMNA (0.43) | LRRK2CHEK1CHEK2 | |
| SCHEMBL23089673 | 0.69 | LRRK2 (0.42) | LRRK2CHEK1CHEK2 | |
| SCHEMBL23114504 | 0.68 | LRRK2 (0.41) | LRRK2CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044641-A2 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |