Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940810 | 0.82 | LRRK2 (0.41) | LRRK2ADORA2AADORA1CHEK1AOC3 | |
| SCHEMBL21941085 | 0.80 | LRRK2 (0.50) | LRRK2ADORA2AADORA1CHEK1CHEK2 | |
| SCHEMBL21940805 | 0.79 | ELOVL1 (0.39) | — | |
| SCHEMBL17623325 | 0.72 | LRRK2 (0.48) | LRRK2CHEK1CHEK2 | |
| SCHEMBL21940286 | 0.71 | ALDH1A1 (0.42) | ADORA2AADORA1 | |
| SCHEMBL21262293 | 0.70 | GRIN2D (0.43) | LRRK2ADORA2AADORA1CHEK1CHEK2 | |
| SCHEMBL21940600 | 0.69 | LRRK2 (0.41) | LRRK2ADORA2AADORA1STK3 | |
| SCHEMBL16440191 | 0.69 | GAA (0.43) | LRRK2SYK | |
| SCHEMBL31200599 | 0.69 | ADORA2A (0.50) | LRRK2ADORA2AADORA1AOC3PTPN11 | |
| SCHEMBL21941081 | 0.68 | AKT1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |