Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.38 |
| ▸ | WNT1 | P04628 | 6/20 | 0.37 |
| ▸ | IDH2 | P48735 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16238636 | 0.96 | RHOA (0.40) | RHOADYRK1AGSK3BWNT1IDH2 | |
| SCHEMBL17624498 | 0.92 | RHOA (0.40) | RHOADYRK1AGSK3BWNT1IDH2 | |
| SCHEMBL17618774 | 0.90 | RHOA (0.42) | RHOADYRK1AGSK3BIDH2KDM4E | |
| SCHEMBL17618361 | 0.87 | ALOX15 (0.43) | IDH2CA2CA9KDM4EUSP2 | |
| SCHEMBL17618812 | 0.87 | RHOA (0.39) | RHOADYRK1AGSK3BWNT1CA2 | |
| SCHEMBL19865069 | 0.87 | RHOA (0.48) | RHOAIDH2CA2CA9LMNA | |
| SCHEMBL16250011 | 0.87 | RHOA (0.48) | RHOAIDH2CA2CA9LMNA | |
| SCHEMBL17778891 | 0.87 | DYRK1A (0.40) | RHOADYRK1AGSK3BWNT1CLK2 | |
| SCHEMBL16249983 | 0.87 | RHOA (0.48) | RHOAIDH2CA2CA9LMNA | |
| SCHEMBL19699109 | 0.87 | DYRK1A (0.39) | RHOADYRK1AGSK3BWNT1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | RHOA 4858/4885DYRK1A 2415/4885GSK3B 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.