Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457 | 0.83 | ALDH1A1 (0.47) | ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL13246056 | 0.83 | KDM4E (0.45) | KDM4EPKMKMT2AMEN1HTT | |
| SCHEMBL228026 | 0.78 | KDM4E (0.44) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL5988002 | 0.75 | PIK3CD (0.43) | KDM4EKMT2AMEN1POLBMAPT | |
| SCHEMBL1768572 | 0.75 | KDM4E (0.41) | KDM4EKMT2AMEN1POLBMAPT | |
| SCHEMBL1768574 | 0.75 | KDM4E (0.41) | KDM4EKMT2AMEN1POLBMAPT | |
| SCHEMBL24772554 | 0.74 | ALOX5 (0.41) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL9957440 | 0.74 | KDM4E (0.40) | KDM4EKMT2APOLBMAPTNPC1 | |
| SCHEMBL15932470 | 0.73 | KDM4E (0.38) | KDM4EPKMKMT2APOLBMAPT | |
| SCHEMBL2718787 | 0.73 | ALOX5 (0.43) | KMT2AMEN1NPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044585-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |