Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626866 | 0.87 | PDE10A (0.44) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL16220761 | 0.84 | PDE10A (0.41) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| Acetic Acid SCHEMBL17626773 | 0.84 | PDE10A (0.48) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL17626699 | 0.82 | ALDH1A1 (0.38) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL18691292 | 0.82 | PDE10A (0.45) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL17626844 | 0.80 | PDE10A (0.47) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL16212515 | 0.79 | ALDH1A1 (0.52) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL18729482 | 0.76 | APP (0.48) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL17626853 | 0.75 | RAB9A (0.59) | PDE10ARAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL17626863 | 0.75 | PDE10A (0.58) | PDE10ARAB9AALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999701-A1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | Hoffmann-La Roche Inc. (US) | 2016-03-30 | — | — | EP | disclosed |