Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628123 | 1.00 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL25224897 | 0.86 | ADRA1D (0.73) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL17628092 | 0.84 | HRH4 (0.55) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL17628089 | 0.84 | HRH4 (0.55) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL4092118 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2ALDH1A1EHMT2NTSR1KDM4E | |
| SCHEMBL30455285 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2ALDH1A1EHMT2NTSR1KDM4E | |
| SCHEMBL3318391 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1EHMT2NTSR1KDM4E | |
| SCHEMBL17627945 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL17627947 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ADRA1DADRA1BADRA1A | |
| SCHEMBL17627954 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1EHMT2NTSR1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORPORATION (KR) | 2017-06-01 | — | — | US | disclosed |
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORP (KR) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | SMN1; SMN2 3806/4885ALDH1A1 3402/4885ADRA1D 569/4885 |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | SMN1; SMN2 3806/4885ALDH1A1 3402/4885ADRA1D 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.