Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628278 | 1.00 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17628052 | 0.94 | AKT1 (0.49) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| SCHEMBL17628049 | 0.94 | AKT1 (0.49) | OPRM1OPRD1OPRK1OGFRL1AKT1 | |
| SCHEMBL17628114 | 0.84 | PRKDC (0.51) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17628115 | 0.84 | PRKDC (0.51) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17627982 | 0.84 | PRKDC (0.44) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17627980 | 0.84 | PRKDC (0.44) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17628072 | 0.82 | CNR2 (0.47) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17628070 | 0.82 | CNR2 (0.47) | OPRM1OPRD1OPRK1OGFRL1PRKDC | |
| SCHEMBL17628432 | 0.79 | HRH4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORPORATION (KR) | 2017-06-01 | — | — | US | disclosed |
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORP (KR) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | OPRM1 769/4885OPRD1 623/4885OPRK1 977/4885 |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | OPRM1 769/4885OPRD1 623/4885OPRK1 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.