Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628075 | 0.94 | PRKDC (0.39) | HRH4OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL17627935 | 0.92 | PRKDC (0.39) | HRH4OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL17628307 | 0.84 | HRH4 (0.38) | HRH4MEN1KMT2ALMNATSHR | |
| SCHEMBL17628270 | 0.83 | SPR (0.46) | HRH4LMNATSHRNR4A1SMN1; SMN2 | |
| SCHEMBL17628272 | 0.83 | SPR (0.46) | HRH4LMNATSHRNR4A1SMN1; SMN2 | |
| SCHEMBL17667367 | 0.81 | HRH4 (0.36) | HRH4MEN1KMT2ALMNATSHR | |
| SCHEMBL17667365 | 0.81 | HRH4 (0.36) | HRH4MEN1KMT2ALMNATSHR | |
| SCHEMBL17667288 | 0.80 | SPR (0.45) | HRH4LMNATSHRNR4A1SMN1; SMN2 | |
| SCHEMBL17667289 | 0.79 | HRH4 (0.35) | HRH4MEN1KMT2ALMNATSHR | |
| SCHEMBL17667301 | 0.78 | HRH4 (0.36) | HRH4MEN1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORPORATION (KR) | 2017-06-01 | — | — | US | disclosed |
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORP (KR) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | HRH4 4/4885OPRM1 769/4885OPRD1 623/4885 |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | HRH4 4/4885OPRM1 769/4885OPRD1 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.